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However, IR3 can sometimes act as an IGF1 mimetic and especially in cells overexpressing the IGF-1R (Kato et al, 1993)

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Amongst the two distinct types of ALS, the familial form (FALS) accounts for 10% of all ALS cases and 15 to 20% of FALS cases are related to the SOD1 gene mutation, an antioxidant enzyme which scavenges the superoxide radical

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